Cell Responses to Self and Tumor Tissue The Inducible Costimulator Augments Tc17
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Purpose: The adoptive cell transfer (ACT) of CD8þ T cells is a promising treatment for advanced malignancies. Lymphodepletion before ACT enhances IFNgþCD8þ T cell (Tc0)–mediated tumor regression. Yet, how lymphodepletion regulates the function and antitumor activity of IL17AþCD8þ T cells (Tc17) is unknown. Experimental Design: To address this question, pmel-1 CD8þ T cells were polarized to secr...
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It has been shown that certain pathogens can trigger efficient T cell responses in the absence of CD28, a key costimulatory receptor expressed on resting T cells. Inducible costimulator protein (ICOS) is an inducible costimulator structurally and functionally related to CD28. Here, we show that in the absence of CD28 both T helper cell type 1 (Th1) and Th2 responses were impaired but not abroga...
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تاریخ انتشار 2015